A program to evaluate a control system based on feedback of aerodynamic pressure differentials, part 1

The use of pressure differentials in a flight control system was evaluated. The pressure profile around the test surface was determined using two techniques: (1) windtunnel data (actual); and (2) NASA/Langley Single Element Airfoil Computer Program (theoretical). The system designed to evaluate the concept of using pressure differentials is composed of a sensor drive and power amplifiers, actuator, position potentiometer, and a control surface. The characteristics (both desired and actual) of the system and each individual component were analyzed. The desired characteristics of the system as a whole are given. The flight control system developed, the testing procedures and data reduction methods used, and theoretical frequency response analysis are described

S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8.

Germinal centres are important sites for antibody diversification and affinity maturation, and are also a common origin of B cell malignancies. Despite being made up of motile cells, germinal centres are tightly confined within B cell follicles. The cues that promote this confinement are incompletely understood. P2RY8 is a Gα13-coupled receptor that mediates the inhibition of migration and regulates the growth of B cells in lymphoid tissues1,2. P2RY8 is frequently mutated in germinal-centre B cell-like diffuse large B cell lymphoma (GCB-DLBCL) and Burkitt lymphoma1,3-6, and the ligand for this receptor has not yet been identified. Here we perform a search for P2RY8 ligands and find P2RY8 bioactivity in bile and in culture supernatants of several mouse and human cell lines. Using a seven-step biochemical fractionation procedure and a drop-out mass spectrometry approach, we show that a previously undescribed biomolecule, S-geranylgeranyl-L-glutathione (GGG), is a potent P2RY8 ligand that is detectable in lymphoid tissues at the nanomolar level. GGG inhibited the chemokine-mediated migration of human germinal-centre B cells and T follicular helper cells, and antagonized the induction of phosphorylated AKT in germinal-centre B cells. We also found that the enzyme gamma-glutamyltransferase-5 (GGT5), which was highly expressed by follicular dendritic cells, metabolized GGG to a form that did not activate the receptor. Overexpression of GGT5 disrupted the ability of P2RY8 to promote B cell confinement to germinal centres, which indicates that GGT5 establishes a GGG gradient in lymphoid tissues. This work defines GGG as an intercellular signalling molecule that is involved in organizing and controlling germinal-centre responses. As the P2RY8 locus is modified in several other types of cancer in addition to GCB-DLBCL and Burkitt lymphoma, we speculate that GGG might have organizing and growth-regulatory roles in multiple human tissues

On recurrence and ergodicity for geodesic flows on noncompact periodic polygonal surfaces

We study the recurrence and ergodicity for the billiard on noncompact polygonal surfaces with a free, cocompact action of $\Z$ or $\Z^2$. In the $\Z$-periodic case, we establish criteria for recurrence. In the more difficult $\Z^2$-periodic case, we establish some general results. For a particular family of $\Z^2$-periodic polygonal surfaces, known in the physics literature as the wind-tree model, assuming certain restrictions of geometric nature, we obtain the ergodic decomposition of directional billiard dynamics for a dense, countable set of directions. This is a consequence of our results on the ergodicity of \ZZ-valued cocycles over irrational rotations.Comment: 48 pages, 12 figure

HMMER web server: interactive sequence similarity searching

HMMER is a software suite for protein sequence similarity searches using probabilistic methods. Previously, HMMER has mainly been available only as a computationally intensive UNIX command-line tool, restricting its use. Recent advances in the software, HMMER3, have resulted in a 100-fold speed gain relative to previous versions. It is now feasible to make efficient profile hidden Markov model (profile HMM) searches via the web. A HMMER web server (http://hmmer.janelia.org) has been designed and implemented such that most protein database searches return within a few seconds. Methods are available for searching either a single protein sequence, multiple protein sequence alignment or profile HMM against a target sequence database, and for searching a protein sequence against Pfam. The web server is designed to cater to a range of different user expertise and accepts batch uploading of multiple queries at once. All search methods are also available as RESTful web services, thereby allowing them to be readily integrated as remotely executed tasks in locally scripted workflows. We have focused on minimizing search times and the ability to rapidly display tabular results, regardless of the number of matches found, developing graphical summaries of the search results to provide quick, intuitive appraisement of them

Modeling the Large Scale Structures of Astrophysical Jets in the Magnetically Dominated Limit

We suggest a new approach that could be used for modeling both the large scale behavior of astrophysical jets and the magnetically dominated explosions in astrophysics. We describe a method for modeling the injection of magnetic fields and their subsequent evolution in a regime where the free energy is magnetically dominated. The injected magnetic fields, along with their associated currents, have both poloidal and toroidal components, and they are not force free. The dynamic expansion driven by the Lorentz force of the injected fields is studied using 3-dimensional ideal magnetohydrodynamic simulations. The generic behavior of magnetic field expansion, the interactions with the background medium, and the dependence on various parameters are investigated.Comment: Accepted to ApJ, May 10, 2006 issue, 12 figures total (3 color figures

The Cosmological Constant and Advanced Gravitational Wave Detectors

Interferometric gravitational wave detectors could measure the frequency sweep of a binary inspiral [characterized by its chirp mass] to high accuracy. The observed chirp mass is the intrinsic chirp mass of the binary source multiplied by $(1+z)$, where $z$ is the redshift of the source. Assuming a non-zero cosmological constant, we compute the expected redshift distribution of observed events for an advanced LIGO detector. We find that the redshift distribution has a robust and sizable dependence on the cosmological constant; the data from advanced LIGO detectors could provide an independent measurement of the cosmological constant.Comment: 13 pages plus 5 figure, LaTeX. Revised and final version, to appear in Phys. Rev.

Topological Entropy of Braids on the Torus

A fast method is presented for computing the topological entropy of braids on the torus. This work is motivated by the need to analyze large braids when studying two-dimensional flows via the braiding of a large number of particle trajectories. Our approach is a generalization of Moussafir's technique for braids on the sphere. Previous methods for computing topological entropies include the Bestvina--Handel train-track algorithm and matrix representations of the braid group. However, the Bestvina--Handel algorithm quickly becomes computationally intractable for large braid words, and matrix methods give only lower bounds, which are often poor for large braids. Our method is computationally fast and appears to give exponential convergence towards the exact entropy. As an illustration we apply our approach to the braiding of both periodic and aperiodic trajectories in the sine flow. The efficiency of the method allows us to explore how much extra information about flow entropy is encoded in the braid as the number of trajectories becomes large.Comment: 19 pages, 44 figures. SIAM journal styl

The Origin of Black Hole Entropy in String Theory

I review some recent work in which the quantum states of string theory which are associated with certain black holes have been identified and counted. For large black holes, the number of states turns out to be precisely the exponential of the Bekenstein-Hawking entropy. This provides a statistical origin for black hole thermodynamics in the context of a potential quantum theory of gravity.Comment: 18 pages (To appear in the proceedings of the Pacific Conference on Gravitation and Cosmology, Seoul, Korea, February 1-6, 1996.

Binary inspiral, gravitational radiation, and cosmology

Observations of binary inspiral in a single interferometric gravitational wave detector can be cataloged according to signal-to-noise ratio $\rho$ and chirp mass $\cal M$. The distribution of events in a catalog composed of observations with $\rho$ greater than a threshold $\rho_0$ depends on the Hubble expansion, deceleration parameter, and cosmological constant, as well as the distribution of component masses in binary systems and evolutionary effects. In this paper I find general expressions, valid in any homogeneous and isotropic cosmological model, for the distribution with $\rho$ and $\cal M$ of cataloged events; I also evaluate these distributions explicitly for relevant matter-dominated Friedmann-Robertson-Walker models and simple models of the neutron star mass distribution. In matter dominated Friedmann-Robertson-Walker cosmological models advanced LIGO detectors will observe binary neutron star inspiral events with $\rho>8$ from distances not exceeding approximately $2\,\text{Gpc}$, corresponding to redshifts of $0.48$ (0.26) for $h=0.8$ ($0.5$), at an estimated rate of 1 per week. As the binary system mass increases so does the distance it can be seen, up to a limit: in a matter dominated Einstein-deSitter cosmological model with $h=0.8$ ($0.5$) that limit is approximately $z=2.7$ (1.7) for binaries consisting of two $10\,\text{M}_\odot$ black holes. Cosmological tests based on catalogs of the kind discussed here depend on the distribution of cataloged events with $\rho$ and $\cal M$. The distributions found here will play a pivotal role in testing cosmological models against our own universe and in constructing templates for the detection of cosmological inspiraling binary neutron stars and black holes.Comment: REVTeX, 38 pages, 9 (encapsulated) postscript figures, uses epsf.st

Directional approach to spatial structure of solutions to the Navier-Stokes equations in the plane

We investigate a steady flow of incompressible fluid in the plane. The motion is governed by the Navier-Stokes equations with prescribed velocity $u_\infty$ at infinity. The main result shows the existence of unique solutions for arbitrary force, provided sufficient largeness of $u_\infty$. Furthermore a spacial structure of the solution is obtained in comparison with the Oseen flow. A key element of our new approach is based on a setting which treats the directino of the flow as \emph{time} direction. The analysis is done in framework of the Fourier transform taken in one (perpendicular) direction and a special choice of function spaces which take into account the inhomogeneous character of the symbol of the Oseen system. From that point of view our technique can be used as an effective tool in examining spatial asymptotics of solutions to other systems modeled by elliptic equations